PRKCI, protein kinase C iota, 5584

N. diseases: 78; N. variants: 3
Disease: Esophageal Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.030 GeneticVariation group BEFREE To investigate further the role of PRKCI alteration in esophageal tumors, a tissue microarray containing samples from 180 ESCCs was used for immunohistochemistry analysis. 17990328 2008
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.030 Biomarker group BEFREE These results suggested that PKCι positively regulated β-catenin through negatively regulated autophagy and depletion of PKCι promoted apoptosis via autophagic degradation of β-catenin in esophageal cancer cells. 23359356 2014
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.030 Biomarker group BEFREE In vivo experiments showed that PKCι suppression decreased tumor growth in esophageal cancer xenografts and lung metastases in nude mice. 21310827 2011